Postdoctoral Grant
Improve Diagnosis of Sepsis through Analysis of Fragmentation Patterns in Plasma Cell-free DNA
Awarded in 2024
Sepsis is a life-threatening condition that is difficult to diagnose quickly in critically ill patients. Current tests, such as microbial cultures, are slow and often lack sensitivity, delaying treatment and increasing risks. This project will develop computational methods to analyze cell-free DNA (cfDNA) fragmentation patterns in blood as a rapid, low-cost tool to detect sepsis and identify infection sites. By studying DNA released from damaged tissues, the research aims to distinguish sepsis from non-infectious inflammation and monitor patient response to treatment.