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Funded Projects

Preclinical evaluation of a novel theranostic MET-directed variable new antigen receptor (VNAR) single-domain antibody in MET-altered lung cancer

Awarded in 2024
Collaborative Health Sciences Program
Updated Apr 24, 2025

At a Glance

This project aims to develop a novel treatment for non-small cell lung cancer, the leading cause of cancer death in the United States and Wisconsin, by using a unique shark-derived antibody. The goal is to improve treatment outcomes for patients who have an abnormal MET protein and a generally worse prognosis. Researchers will focus on creating a highly targeted therapy that combines radiation with this specialized antibody to attack cancer cells more effectively.

More Funded Projects

research icon: microscope and stethoscope
Collaborative Health Sciences Program

Proteomic exploration of lung matrisome in pulmonary fibrosis: role of MRC2

Year Awarded: 2024
Idiopathic pulmonary fibrosis (IPF) is a fatal lung condition where tissue becomes scarred and hardened, and its prevalence in the United States is increasing. Using cutting edge proteomics and bioinformatics technologies and methodologies, researchers aim to better understand how fibrosis happens in order to find ways to reverse it. The project will lay the groundwork for the development of precise therapeutics tailored to combat fibrotic lung alterations.
research icon: microscope and stethoscope
Collaborative Health Sciences Program

Piloting Badger-Seq: a revolutionary paradigm for the genomic diagnosis of critically ill newborns

Year Awarded: 2024
Infants born with a rare genetic disorder or birth defect experience high acuity, prolonged hospital stays and a lifetime of health challenges. Molecular diagnosis is key to caring for these infants, and speed is critical. This multidisciplinary team of researchers will use an approach to screening using artificial intelligence and a revolutionary genome sequencing platform to bring state-of-the-art ultra-rapid genome sequencing to infants in hospitals across Wisconsin.