Next-generation Radiotherapeutics: ¹⁶¹Tb-ART-101 Toward Curative Therapy for Advanced Prostate Cancer

Awarded in 2025

Updated Dec 3, 2025

At a Glance

The project, Next-generation Radiotherapeutics: ¹⁶¹Tb-ART-101 Toward Curative Therapy for Advanced Prostate Cancer, led by research associate Malick Bio Idrissou, PhD, aims to develop a next-generation radiotherapeutic designed to more effectively treat advanced prostate cancer. Using Terbium-161 (¹⁶¹Tb) paired with a highly targeted agent called ART-101, the approach delivers precise radiation directly to cancer cells while sparing surrounding healthy tissue. This study will test the therapy in advanced disease models that better reflect human tumor biology and immune responses, with the goal of identifying the tumor subtypes most likely to benefit and accelerate progress toward future clinical trials. Reinier Hernandez, PhD, assistant professor, Department of Medical Physics, serves as the supervising mentor.

More Funded Projects

research icon: microscope and stethoscope

Postdoctoral Grant

Awarded in 2025

The project, Nutritional Influence on Microbiota and Immune Responses During Cryptosporidium Infections, led by research associate Bethany Korwin-Mihavics, PhD, investigates how nutrition and gut microbiota shape the body’s response to Cryptosporidium, a parasite that causes severe gastrointestinal illness. Using experimental models, the study explores how malnutrition-associated changes in the gut microbiome influence susceptibility to infection and alter immune responses. By identifying microbial communities that worsen disease and clarifying the mechanisms behind these interactions, this work aims to inform the development of future therapies for Cryptosporidium and potentially other intestinal parasites. Margaret Alexander, PhD, assistant professor in the Department of Medical Microbiology and Immunology, serves as the supervising mentor.

Postdoctoral Grant

Awarded in 2025

The project, Modeling the Diabetic Heart in Engineered Heart Tissue, led by postdoctoral fellow Angela Greenman, PhD, aims to improve understanding of how type 2 diabetes affects the heart by developing a new stem cell–based model of diabetic heart tissue. By engineering human heart tissue that reflects the biology of diabetes, this study will provide a platform to examine how the disease develops and progresses. The project also incorporates specialized training in a novel technique for assessing the relaxation phase of the heartbeat, which is a common problem for individuals with type 2 diabetes. J. Carter Ralphe, MD, professor and division chief, Department of Pediatrics, Division of Cardiology, serves as the supervising mentor.