Assessing brain and cardiovascular health during gender-affirming hormone therapy

Awarded in 2025
Updated Apr 24, 2025

At a Glance

This research will study brain and cardiovascular health in transgender adult patients receiving gender-affirming hormone therapy at two timepoints: before hormone therapy begins, and after four to six months of therapy. The goal of the study is to assess links between gender affirming hormone therapy, cardiovascular health and brain structure and function. MRI will be used to analyze brain structure and brain blood flow. Body fat will be assessed by Dual X-ray Absorptiometry and aerobic fitness will be assessed using a treadmill test. This analysis is also relevant to other conditions involving hormone disruptions such as puberty, menopause, pregnancy, aging, postpartum, diabetes and obesity.

research icon: microscope and stethoscope
PERC Opportunity Grant

Enabling Clinicians and Healthcare Trainees to Improve the Care of Wisconsin Residents Living with Dementia


Year Awarded: 2019
This project aimed to improve the care of Wisconsin residents living with dementia by increasing primary care provider and trainees’ knowledge and skills related to dementia diagnosis and management of the behavioral and psychological symptoms of dementia (BPSD). Alzheimer’s disease currently affects 110,000 Wisconsinites and the number is expected to increase to 130,000 by 2025. About 90 percent of individuals with dementia experience BPSD, which includes depression, physical aggression, wandering and sleep disturbance, among others. As a result, there is a need to train future and practicing primary care clinicians in the identification and management of BPSD to help caregivers manage these behaviors in the home setting, potentially preventing crisis escalation and unnecessary institutionalization. The project successfully increased medical trainees’ and primary care providers’ knowledge and skills in dementia diagnosis and BPSD management. A web-based curriculum for third- and fourth-year medical students at the University of Wisconsin School of Medicine and Public Health improved students’ self-reported attitudes towards dementia care and informed the design of a new Dementia and Public Health elective that began in 2023. Additionally, academic detailing sessions for primary care providers at Richland Center Hospital and Milwaukee Health Services resulted in significant knowledge gains and improved confidence in managing BPSD. Lastly, the DICE Approach was used to train social workers, nurses, medical assistants and assisted living and nursing home frontline staff and led to increased knowledge, self-efficacy and comfort in managing BPSD.