Assessing Adult Brain and Cardiovascular Health During Gender-Affirming Hormone Therapy
At a Glance
This research will study brain and cardiovascular health in transgender adult patients receiving gender-affirming hormone therapy at two timepoints: before hormone therapy begins, and after four to six months of therapy. The goal of the study is to assess links between gender affirming hormone therapy, cardiovascular health and brain structure and function. MRI will be used to analyze brain structure and brain blood flow. Body fat will be assessed by Dual X-ray Absorptiometry and aerobic fitness will be assessed using a treadmill test. This analysis is also relevant to other conditions involving hormone disruptions such as puberty, menopause, pregnancy, aging, postpartum, diabetes and obesity.
Collaborators: Veena Nair, PhD, scientist, Department of Radiology; Oliver Wieben, PhD, professor, Departments of Medical Physics and Radiology; Kevin Johnson, PhD, associate professor, Departments of Medical Physics and Radiology; Jen Rehm, MD, associate professor, Department of Pediatrics; Dawn Davis, MD, PhD, professor, Department of Medicine