Disrupting DNA Damage Repair to Potentiate the Efficacy of Radiopharmaceutical Theranostic Agents in Advanced Prostate Cancer

The project, GATA2 Regulated Piezo1 Controls Uterine Serous Carcinoma Invasion, led by Daniel Matson, MD, PhD, investigates how the interaction between the proteins GATA2 and Piezo1 drives invasion in uterine serous carcinoma, a rare but extremely aggressive form of uterine cancer that contributes to cancer deaths among postmenopausal women. Building on findings that GATA2 may help predict which tumors are likely to recur, the study uses patient-derived cancer cells and mouse models to understand how these factors work together to promote tumor spread. By clarifying these mechanisms, the project aims to improve risk stratification, allowing clinicians to spare low-risk patients from unnecessary chemotherapy while directing more intensive treatment to those at highest risk. Collaborators include Lisa Barroilhet, MD, associate professor, Department of Obstetrics and Gynecology, and Pam Kreeger, PhD, professor, Department of Pathology and Laboratory Medicine, UW–Madison.