Collaborative Health Sciences Program
PI3K/PTEN Targeted Therapy for HPV-associated Cancers
Year Awarded:
2015
This research studied common genetic changes in a gene called PI3K, a type of mutation found frequently in HPV-associated anal, head, and neck cancers, with the goal of advancing knowledge to inform choices of anticancer drugs for HPV-associated cancers.
The researchers found that these genetic changes drove development of cancers in mice, but that drugs targeting PI3K did not necessarily inhibit human cancers, indicating a need to develop additional steps to assess whether a cancer will respond to a targeted drug therapy. A new type of culture system, called the tumor spheroid culture system, may provide that means.