New Investigator Program
Defining New Paradigms for Epithelial-Immune Interactions in Dysbiosis by Understanding the Response of Tuft Cells to Commensal Microbes
Awarded in 2025
The gut microbiome plays a key role in our health, but poor diets and disease can disrupt its balance, leading to dysbiosis. In Wisconsin, where obesity rates are high, dysbiosis worsens conditions like Inflammatory Bowel Disease and increases the risk of metabolic syndrome. This study investigates how tuft cells, which are specialized gut cells, help maintain intestinal health and immune responses. Findings will enhance understanding of microbiome-gut interactions and guide the analysis of tissue samples from patients with dysbiosis and inflammatory diseases.